Eli is a Synthetic Biologist with proven success in all aspects of strain development for Fuel and Specialty Chemical production including: pathway optimization, enzyme evolution, genetic modification, protein/pathway/whole strain mutagenesis, fermentation, and scale up. Eli spent over 10 years of his life engineering microbes. Prior to Autodesk, Eli led a group at Intrexon Corporation to engineer a microbe to upgrade natural gas to liquid fuels and chemicals. Before this, Eli worked on the green chemicals team at LS9, Inc, where he engineered a microbial strain to bring a fatty alcohol production process from proof of concept to demonstration scale. Prior to his work in Synthetic Biology and metabolic engineering, Eli spent a few years developing computational models for protein structure design and optimization. He received his PhD in Biophysics from the University of California, San Francisco, where he worked with Professor Matthew Jacobson and Professor Christopher Voigt. His thesis work combined computational protein structure prediction and the re-wiring of bacterial signaling systems. He has a B.A. in Chemistry from Williams College. Eli has a strong publishing record with 8 publications in peer reviewed journals coming from his undergraduate and graduate work. He also contributed a chapter for the book Systems Biology and Biotechnology of E. coli. In his 7 years post graduate school, Eli has 6 patent applications on the development of new technologies for engineering proteins, metabolic pathways, and whole microbes.
Coleman W, Vidanes G, Cottarel G, Muley S, Kaminura R, Javan A, Sun J, Groban E. Biological conversion of multi-carbon compounds from methane. PCT/US2014/0273128. September 2014.
Greenfield D, Clarke E, Groban E, Arlagadda V, Lee S, Li X, Hu Z, Zhu B. Car enzymes and improved production of fatty alcohols. PCT/US2013/035040. March 2014.
Greenfield D, Schirmer A, Clarke E, Groban E, daCosta B, Hu Z. Improved production of fatty acid derivatives. PCT/US2013/035037. December 2013.
Groban E, Arlagadda V, Frykman S, Greenfield D, Hu Z. Production of fatty acids and derivatives thereof having improved aliphatic chain length and saturation characteristics. PCT/US2012/048620. February 2013.
Arlagadda V, Frykmann S, Greenfield D, Groban E, Hom L, Hu Z, Sanchez-Riera. Methods and compositions for improved production of fatty acids and derivatives thereof. PCT/US2012/031881. November 2012.
Hom L, Trinh N, Alibhai M, Hu Z, Groban E, Arlagadda V, Clarke L. Methods and compositions related to thioesterase enzymes. US 12/645,497. June 2010.
Selected Invited Oral Presentations:
“Bioconversion of natural gas to fuels and chemicals: A symphony of metabolic and chemical engineering.” Society for Industrial Microbiology Annual Meeting. August 2015.
“Methane bioconversion to chemicals, lubricants, and fuels.” UC Berkeley Bioengineering Graduate School. April 2015.
“Methane bioconversion to chemicals, lubricants, and fuels.” SynBioBeta Conference. November 2014.
“Methane bioconversion to chemicals, lubricants and fuels.” Society for Industrial Microbiology Annual Meeting. July 2014.
“What is industrial synthetic biology?” UC Berkeley Bioengineering Graduate School. April 2013.
“What is industrial synthetic biology?” University of Washington Department of Chemical Engineering. February 2013.
“Intrexon and the Industrial Products Division.” SynBioBeta Conference. November 2012.
“What is industrial synthetic biology?” UC Berkeley Bioengineering Graduate School. August 2012.
“More than just a pipe dream? The enabling role of synthetic biology in the future bio-economy.” UC Berkeley Bioengineering Graduate School. April 2012.
“Synthetic Biology Applications in the Rapid Development of Renewable Fuels and Chemicals.” Berkeley Public High School. April 2011.
“Synthetic Biology Applications in the Rapid Development of Renewable Fuels and Chemicals.” Santa Clara University Engineering Department. February 2011.
“Study and design of bacterial signaling systems,” Bay Area Microbial Pathogenesis Symposium. March 2008.
“Study and design of signaling systems in bacteria,” Massachusetts Institute of Technology. November 2007.
“Study and design of signaling systems in bacteria,” Harvard Medical School. November 2007.
San Francisco, CA 94111